A DNA-protein nanoengine for "On-Demand" release and precise delivery of molecules

被引：55

作者：

Nutiu, R

Li, YF ^{[1
]}

机构：

[1] McMaster Univ, Dept Biochem & Biomed Sci, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Dept Chem, Hamilton, ON L8N 3Z5, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 34期

关键词：

aptamers; DNA; enzymes; molecular devices; nanotechnology;

D O I：

10.1002/anie.200501214

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A DNA aptamer (green in the scheme), an antisense DNA strand (purple), and an enzyme (blue) form a nanoengine that responds to a small-molecule input (red) and dispatches a DNA output. The addition of the input promotes the first stroke of the nanoengine, the action of the enzyme the second stroke. Joint exploration of all components could lead to bionanodevices that can detect a biological malfunction and initiate a repair. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

收藏

页码：5464 / 5467

页数：4

相关论文

共 40 条

[1] MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].

ADLEMAN, LM .

SCIENCE, 1994, 266 (5187) :1021-1024

[2] DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].

Alberti, P ;

Mergny, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573

[3] Materials science - Smart biomaterials [J].

Anderson, DG ;

Burdick, JA ;

Langer, R .

SCIENCE, 2004, 305 (5692) :1923-1924

[4] DNA molecule provides a computing machine with both data and fuel [J].

Benenson, Y ;

Adar, R ;

Paz-Elizur, T ;

Livneh, Z ;

Shapiro, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (05) :2191-2196

[5] Programmable and autonomous computing machine made of biomolecules [J].

Benenson, Y ;

Paz-Elizur, T ;

Adar, R ;

Keinan, E ;

Livneh, Z ;

Shapiro, E .

NATURE, 2001, 414 (6862) :430-434

[6] Solution of a 20-variable 3-SAT problem on a DNA computer [J].

Braich, RS ;

Chelyapov, N ;

Johnson, C ;

Rothemund, PWK ;

Adleman, L .

SCIENCE, 2002, 296 (5567) :499-502

[7] SYNTHESIS FROM DNA OF A MOLECULE WITH THE CONNECTIVITY OF A CUBE [J].

CHEN, JH ;

SEEMAN, NC .

NATURE, 1991, 350 (6319) :631-633

[8] An autonomous DNA nanomotor powered by a DNA enzyme [J].

Chen, Y ;

Wang, MS ;

Mao, CD .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (27) :3554-3557

[9] Building programmable jigsaw puzzles with RNA [J].

Chworos, A ;

Severcan, I ;

Koyfman, AY ;

Weinkam, P ;

Oroudjev, E ;

Hansma, HG ;

Jaeger, L .

SCIENCE, 2004, 306 (5704) :2068-2072

[10] A DNA-based machine that can cyclically bind and release thrombin [J].

Dittmer, WU ;

Reuter, A ;

Simmel, FC .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (27) :3550-3553

← 1 2 3 4 →