A photolabile carbamate based dual linker analytical construct for facile monitoring of solid phase chemistry: 'TLC' for solid phase?

被引：53

作者：

McKeown, SC

Watson, SP

Carr, RAE

Marshall, P

机构：

[1] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Discovery Chem Unit, Stevenage SG1 2NY, Herts, England

[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Phys Sci Unit, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(99)00115-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A dual linker analytical construct based on a photolabile carbamate is described. Photochemical cleavage from the solid support can be effected to afford an analytical fragment, containing the substrate, which is sensitised to electrospray mass spectrometry. We believe this simple construct now renders all substrates visible to high throughput mass specroscopic analysis. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2407 / 2410

页数：4

共 11 条

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