Molecular epidemiology of invasive methicillin-susceptible Staphylococcus aureus strains circulating at a Swiss University Hospital

被引：36

作者：

Fenner, L. ^{[1
]}

Widmer, A. F. ^{[2
,3
]}

Frei, R. ^{[1
]}

机构：

[1] Univ Basel Hosp, Microbiol Lab, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Div Infect Dis, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Hosp Epidemiol, CH-4031 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2008年 / 27卷 / 07期

关键词：

D O I：

10.1007/s10096-008-0463-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In contrast to methicillin-resistant Staphylococcus aureus, little is known of the distribution of spa types among methicillin-susceptible S. aureus (MSSA). We have analyzed 101 nonrepetitive invasive MSSA isolates from infected patients, consecutively isolated during 14 months between 2006 and 2007 at University Hospital Basel. They were genetically characterized according to S. aureus protein A (spa) types and important virulence-associated genes. Sixty-five different spa types corresponding to nine different spa clonal complexes were observed. Analysis of different virulence genes showed a frequency of 17% for toxic-shock syndrome toxin and 5% for exfoliative toxin D. In conclusion, spa typing revealed a great genetic diversity without predominant spa type, not providing evidence for clonal spreading.

引用

页码：623 / 626

页数：4

共 11 条

[1] Comparison of genetic backgrounds of methicillin-resistant and -susceptible Staphylococcus aureus isolates from Portuguese hospitals and the community [J].

de Sousa, MA ;

Conceiçao, T ;

Simas, C ;

de Lencastre, H .

JOURNAL OF CLINICAL MICROBIOLOGY, 2005, 43 (10) :5150-5157

[2] Genetic relatedness between methicillin-susceptible and methicillin-resistant Staphylococcus aureus:: results of a national survey [J].

Hallin, M. ;

Denis, O. ;

Deplano, A. ;

De Mendonca, R. ;

De Ryck, R. ;

Rottiers, S. ;

Struelens, M. J. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2007, 59 (03) :465-472

[3] Course and outcome of Staphylococcus aureus bacteraemia:: a retrospective analysis of 308 episodes in a Swiss tertiary-care centre [J].

Kaech, C ;

Elzi, L ;

Sendi, P ;

Frei, R ;

Laifer, G ;

Bassetti, S ;

Fluckiger, U .

CLINICAL MICROBIOLOGY AND INFECTION, 2006, 12 (04) :345-352

[4] Heterogeneity of methicillin-susceptible Staphylococcus aureus strains at a German university hospital implicates the circulating-strain pool as a potential source of emerging methicillin-resistant S-aureus clones [J].

Layer, F. ;

Ghebremedhin, B. ;

Konig, W. ;

Konig, B. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (06) :2179-2185

[5] Involvement of Panton-Valentine leukocidin-producing Staphylococcus aureus in primary skin infections and pneumonia [J].

Lina, G ;

Piémont, Y ;

Godail-Gamot, F ;

Bes, M ;

Peter, MO ;

Gauduchon, V ;

Vandenesch, F ;

Etienne, J .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) :1128-1132

[6] Multiplex PCR for detection of genes for Staphylococcus aureus enterotoxins, exfoliative toxins, toxic shock syndrome toxin 1, and methicillin resistance [J].

Mehrotra, M ;

Wang, G ;

Johnson, WM .

JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (03) :1032-1035

[7] Throat swabs are necessary to reliably detect carriers of Staphylococcus aureus [J].

Mertz, Dominik ;

Frei, Reno ;

Jaussi, Barbara ;

Tietz, Andreas ;

Stebler, Christine ;

Flueckiger, Ursula ;

Widmer, Andreas F. .

CLINICAL INFECTIOUS DISEASES, 2007, 45 (04) :475-477

[8] Clinical and epidemiologic characteristics cannot distinguish community-associated methicillin-resistant Staphylococcus aureus infection from methicillin-susceptible S-aureus infection:: A prospective investigation [J].

Miller, Loren G. ;

Perdreau-Remington, Franciose ;

Bayer, Arnold S. ;

Diep, Binh ;

Tan, Nelly ;

Bharadwa, Kiran ;

Tsui, Jennifer ;

Perlroth, Joshua ;

Shay, Anthony ;

Tagudar, Grace ;

Ibebuogu, Uzoma ;

Spellberg, Brad .

CLINICAL INFECTIOUS DISEASES, 2007, 44 (04) :471-482

[9] Assignment of Staphylococcus isolates to groups by spa typing, SmaI macrorestriction analysis, and multilocus sequence typing [J].

Strommenger, B. ;

Kettlitz, C. ;

Weniger, T. ;

Harmsen, D. ;

Friedrich, A. W. ;

Witte, W. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (07) :2533-2540

[10] Staphylococcus aureus strains isolated from bloodstream infections changed significantly in 2006 [J].

van der Mee-Marquet, Nathalie ;

Epinette, Christophe ;

Loyau, Jeremy ;

Arnault, Laurence ;

Domelier, Anne-Sophie ;

Losfelt, Barbara ;

Girard, Nicole ;

Quentin, Roland .

JOURNAL OF CLINICAL MICROBIOLOGY, 2007, 45 (03) :851-857

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