Molecular epidemiology of invasive methicillin-susceptible Staphylococcus aureus strains circulating at a Swiss University Hospital

被引：36

作者：

Fenner, L. ^{[1
]}

Widmer, A. F. ^{[2
,3
]}

Frei, R. ^{[1
]}

机构：

[1] Univ Basel Hosp, Microbiol Lab, CH-4031 Basel, Switzerland

[2] Univ Basel Hosp, Div Infect Dis, CH-4031 Basel, Switzerland

[3] Univ Basel Hosp, Hosp Epidemiol, CH-4031 Basel, Switzerland

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2008年 / 27卷 / 07期

关键词：

D O I：

10.1007/s10096-008-0463-0

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

In contrast to methicillin-resistant Staphylococcus aureus, little is known of the distribution of spa types among methicillin-susceptible S. aureus (MSSA). We have analyzed 101 nonrepetitive invasive MSSA isolates from infected patients, consecutively isolated during 14 months between 2006 and 2007 at University Hospital Basel. They were genetically characterized according to S. aureus protein A (spa) types and important virulence-associated genes. Sixty-five different spa types corresponding to nine different spa clonal complexes were observed. Analysis of different virulence genes showed a frequency of 17% for toxic-shock syndrome toxin and 5% for exfoliative toxin D. In conclusion, spa typing revealed a great genetic diversity without predominant spa type, not providing evidence for clonal spreading.

引用

页码：623 / 626

页数：4