Calcium and mitochondria: mechanisms and functions of a troubled relationship

被引：101

作者：

Bianchi, K

Rimessi, A

Prandini, A

Szabadkai, G

Rizzuto, R

机构：

[1] Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy

[2] Univ Ferrara, Interdisciplinary Ctr Study Inflammat, I-44100 Ferrara, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1742卷 / 1-3期

关键词：

mitochondria; endoplasmic reticulum; calcium; ATP; microdomain; apoptosis;

D O I：

10.1016/j.bbamcr.2004.09.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria promptly respond to Ca2+-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca2+ transport, (ii) the physiological/pathological role of mitochondrial Ca2+ uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca2+ probes that allowed the "rediscovery" of these organelles in calcium signalling. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：119 / 131

页数：13

共 110 条

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