Calcium and mitochondria: mechanisms and functions of a troubled relationship

被引：101

作者：

Bianchi, K

Rimessi, A

Prandini, A

Szabadkai, G

Rizzuto, R

机构：

[1] Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy

[2] Univ Ferrara, Interdisciplinary Ctr Study Inflammat, I-44100 Ferrara, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1742卷 / 1-3期

关键词：

mitochondria; endoplasmic reticulum; calcium; ATP; microdomain; apoptosis;

D O I：

10.1016/j.bbamcr.2004.09.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria promptly respond to Ca2+-mediated cell stimulations with a rapid accumulation of the cation into the matrix. In this article, we review (i) the basic principles of mitochondrial Ca2+ transport, (ii) the physiological/pathological role of mitochondrial Ca2+ uptake, (iii) the regulatory mechanisms that may operate in vivo, and (iv) the new targeted Ca2+ probes that allowed the "rediscovery" of these organelles in calcium signalling. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：119 / 131

页数：13

共 110 条

[31] Insight into mitochondrial structure and function from electron tomography
Frey, TG
Renken, CW
Perkins, GA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2002, 1555 (1-3): : 196 - 203
[32] Ca2+ homeostasis during mitochondrial fragmentation and perinuclear clustering induced by hFis1
Frieden, M
James, D
Castelbou, C
Danckaert, A
Martinou, JC
Demaurex, N
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (21) : 22704 - 22714
[33] Selective, high-resolution fluorescence imaging of mitochondrial Ca2+ concentration
Gerencsér, AA
Adam-Vizi, V
[J]. CELL CALCIUM, 2001, 30 (05) : 311 - 321
[34] Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca2+ current ICRAC
Gilabert, JA
Parekh, AB
[J]. EMBO JOURNAL, 2000, 19 (23) : 6401 - 6407
[35] Calcium binding and translocation by the voltage-dependent anion channel: a possible regulatory mechanism in mitochondrial function
Gincel, D
Zaid, H
Shoshan-Barmatz, V
[J]. BIOCHEMICAL JOURNAL, 2001, 358 (358) : 147 - 155
[36] The pathophysiology of mitochondrial cell death
Green, DR
Kroemer, G
[J]. SCIENCE, 2004, 305 (5684) : 626 - 629
[37] Mitochondrial calcium transport: mechanisms and functions
Gunter, TE
Buntinas, L
Sparagna, G
Eliseev, R
Gunter, K
[J]. CELL CALCIUM, 2000, 28 (5-6) : 285 - 296
[38] Calcium signaling and apoptosis
Hajnóczky, G
Davies, E
Madesh, M
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 304 (03) : 445 - 454
[39] Mitochondria suppress local feedback activation of inositol 1,4,5-trisphosphate receptors by Ca2+
Hajnóczky, G
Hager, R
Thomas, AP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) : 14157 - 14162
[40] DECODING OF CYTOSOLIC CALCIUM OSCILLATIONS IN THE MITOCHONDRIA
HAJNOCZKY, G
ROBBGASPERS, LD
SEITZ, MB
THOMAS, AP
[J]. CELL, 1995, 82 (03) : 415 - 424

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