Calcium signaling and apoptosis

被引：408

作者：

Hajnóczky, G ^{[1
]}

Davies, E ^{[1
]}

Madesh, M ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Dept Pathol Anat & Cell Biol, Philadelphia, PA 19107 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 03期

关键词：

apoptosis; calcium signaling; mitochondria; Bcl-2; bid; VDAC; cardiolipin; ROS;

D O I：

10.1016/S0006-291X(03)00616-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ca2+ is one of the key regulators of cell survival, but Ca2+ can also induce apoptosis in response to a variety of pathological conditions. The pro-apoptotic effects of Ca2+ are mediated by a diverse range of Ca2+-sensitive factors that are compartmentalized in various intracellular organelles including the ER, cytoplasm, and mitochondria. The Ca2+ dynamics of these organelles appear to be modulated by the apoptosis-regulating Bcl-2 family proteins. In this paper, the recent progress of research on the mechanisms mediating the apoptosis-regulating effects of Ca2+ and the interactions of Bcl-2 family proteins with the Ca2+ storage organelles are discussed. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

页码：445 / 454

页数：10

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