Cellular senescence: when bad things happen to good cells

被引：3558

作者：

Campisi, Judith

di Fagagna, Fabrizio d'Adda

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

[2] Buck Inst Age Res, Novato, CA 94945 USA

[3] IFOM Fdn, FIRC Inst Mol Oncol, I-20139 Milan, Italy

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 09期

关键词：

D O I：

10.1038/nrm2233

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Cells continually experience stress and damage from exogenous and endogenous sources, and their responses range from complete recovery to cell death. Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing.

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收藏

页码：729 / 740

页数：12

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