Validation of estimated renal function measurements compared with the isotopic glomerular filtration rate in an HIV-infected cohort

被引：26

作者：

Bonjoch, Anna ^{[1
]}

Bayes, Beatriz ^{[2
]}

Riba, Joaquim ^{[3
]}

Puig, Jordi ^{[1
]}

Estany, Carla ^{[1
]}

Perez-Alvarez, Nuria ^{[1
,4
]}

Clotet, Bonaventura ^{[1
,5
]}

Negredo, Eugenia ^{[1
]}

机构：

[1] Univ Hosp Germans Trias, Lluita SIDA Fdn, Barcelona 08916, Spain

[2] Univ Hosp Germans Trias, Serv Nephrol, Barcelona 08916, Spain

[3] Univ Hosp Germans Trias, Nucl Med Serv, Barcelona 08916, Spain

[4] Tech Univ Catalunya, Barcelona, Spain

[5] IrsiCaixa Fdn, Barcelona, Spain

来源：

ANTIVIRAL RESEARCH | 2010年 / 88卷 / 03期

关键词：

HIV infection; Renal function; Isotopic glomerular filtration rate; Cystatin C; Modification of Diet in Renal Disease (MDRD) equation; Cockcroft-Gault equation; Chronic Kidney Disease Epidemiology; Collaboration (CKD-EPI) equation; CHRONIC KIDNEY-DISEASE; TENOFOVIR DISOPROXIL FUMARATE; CYSTATIN-C; SERUM CREATININE; RISK-FACTORS; EQUATION; DYSFUNCTION; PREDICTORS; FAILURE; MARKER;

D O I：

10.1016/j.antiviral.2010.09.015

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We performed a cross-sectional study to determine the best method for estimating the glomerular filtration rate (GFR) in HIV-infected subjects. Isotopic GFR was correlated with 24-h urine creatinine clearance, cystatin C levels, and 3 creatinine-based equations-the Modification of Diet in Renal Disease (MDRD), Cockcroft-Gault (CG), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI)-in 15 patients. Cystatin C showed the strongest correlation with isotopic GFR (r = -0.760,p = 0.001). When cystatin C was used as the reference variable for all 106 patients, CKD-EPI proved to be superior to the other equations (r = -0.671, p < 0.001). Time with HIV infection, unsuppressed viral load, low CD4 T-cell counts, and use of protease inhibitors are related to an increased risk of renal impairment, leading us to recommend early initiation of antiretroviral therapy accompanied by a regular renal study. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：347 / 354

页数：8

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