Glial brain tumor targeting of magnetite nanoparticles in rats

被引:60
作者
Mykhaylyk, O
Cherchenko, A
Ilkin, A
Dudchenko, N
Ruditsa, V
Novoseletz, M
Zozulya, Y
机构
[1] Natl Acad Sci Ukraine, Inst Appl Problems Phys & Biophys, UA-252001 Kiev, Ukraine
[2] Acad Med Sci Ukraine, Inst Neurosurg, UA-254050 Kiev, Ukraine
[3] First Municipal Hosp, Kiev, Ukraine
[4] SII Intermag, Kiev, Ukraine
关键词
contrast agent; ESR; MRI; brain tumor; nanodispersed iron; blood-brain barrier disruption; rat; dextran nanoparticles; glioblastoma; T-2-weighted; tumor imaging;
D O I
10.1016/S0304-8853(00)01264-6
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
After intravenous injection into rats, nanodispersed iron preparations accumulated in internal organs but not in the brain. Hyperosmotic blood-brain barrier disruption followed by injection of magnetite-dextran nanoparticles into the carotid artery resulted in penetration of particles into the brain tumor and peritumoral tissue of the rats bearing glial brain tumor and T-2-weighted magnetic resonance imaging (MRI) images showed pronounced signal loss in the tumor region. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:241 / 247
页数:7
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