Glial brain tumor targeting of magnetite nanoparticles in rats

被引：60

作者：

Mykhaylyk, O

Cherchenko, A

Ilkin, A

Dudchenko, N

Ruditsa, V

Novoseletz, M

Zozulya, Y

机构：

[1] Natl Acad Sci Ukraine, Inst Appl Problems Phys & Biophys, UA-252001 Kiev, Ukraine

[2] Acad Med Sci Ukraine, Inst Neurosurg, UA-254050 Kiev, Ukraine

[3] First Municipal Hosp, Kiev, Ukraine

[4] SII Intermag, Kiev, Ukraine

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

关键词：

contrast agent; ESR; MRI; brain tumor; nanodispersed iron; blood-brain barrier disruption; rat; dextran nanoparticles; glioblastoma; T-2-weighted; tumor imaging;

D O I：

10.1016/S0304-8853(00)01264-6

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

After intravenous injection into rats, nanodispersed iron preparations accumulated in internal organs but not in the brain. Hyperosmotic blood-brain barrier disruption followed by injection of magnetite-dextran nanoparticles into the carotid artery resulted in penetration of particles into the brain tumor and peritumoral tissue of the rats bearing glial brain tumor and T-2-weighted magnetic resonance imaging (MRI) images showed pronounced signal loss in the tumor region. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：241 / 247

页数：7

共 21 条

[1]

Bulte J W, 1993, Acta Neurochir Suppl (Wien), V57, P30

[2]

Bulte JWM, 1997, SCIENTIFIC AND CLINICAL APPLICATIONS OF MAGNETIC CARRIERS, P527

[3] Heme and the endothelium - Effects of nitric oxide on catalytic iron and heme degradation by heme oxygenase [J].