Potential antitumor agents .24. Synthesis and pharmacological behavior of imidazo[2,1-b]thiazole guanylhydrazones bearing at least one chlorine

被引：43

作者：

Andreani, A ^{[1
]}

Rambaldi, M ^{[1
]}

Leoni, A ^{[1
]}

Locatelli, A ^{[1
]}

Bossa, R ^{[1
]}

Fraccari, A ^{[1
]}

Galatulas, I ^{[1
]}

Salvatore, G ^{[1
]}

机构：

[1] UNIV MILAN,DIPARTIMENTO FARMACOL CTM,I-20129 MILAN,ITALY

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 39卷 / 14期

关键词：

D O I：

10.1021/jm9509307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In connection with a previous research dealing with the antitumor activity of imidazo[2,1-b]-thiazole guanylhydrazones, this paper reports the synthesis of new derivatives which were tested for antitumor and positive inotropic activity. In most cases the cytotoxic data from the in vitro experiments (HeLa) were in agreement with the antitumor data in vivo (Ehrlich). The active compounds bear a phenyl ring at the 6 position. On the other hand, the most active cardiotonic agents were devoid of the phenyl ring.

引用

页码：2852 / 2855

页数：4

共 25 条

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