SYNTHESIS AND MITOGENIC ACTIVITY OF NEW IMIDAZO[2,1-B]THIAZOLES

被引：25

作者：

ANDREANI, A ^{[1
]}

RAMBALDI, M ^{[1
]}

LOCATELLI, A ^{[1
]}

ISETTA, AM ^{[1
]}

机构：

[1] FARMITALIA CARLO ERBA SPA,IMMUNOL LINE RES & DEV,NERVIANO,ITALY

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1991年 / 26卷 / 03期

关键词：

IMIDAZO[2,1-B]THIAZOLES; LEVAMISOLE; MITOGENIC ACTIVITY; IMMUNOMODULATION;

D O I：

10.1016/0223-5234(91)90067-W

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight new imidazo[2,1-b]thiazoles were synthesized in order to evaluate their ability to stimulate the proliferation of thymic lymphocytes. The 2-chloro (5-8) proved more active than the 2,3-dimethyl derivatives (1-4): in particular compounds 6 and 7 were more active than levamisole.

引用

页码：335 / 337

页数：3

共 28 条

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[2] ANDREANI A, 1986, EUR J MED CHEM, V21, P55
[3] POTENTIAL ANTI-TUMOR AGENTS .7. 5-SUBSTITUTED 6-PHENYLIMIDAZO[2,1-B]THIAZOLES
ANDREANI, A
BONAZZI, D
RAMBALDI, M
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[4] SYNTHESIS AND DIURETIC ACTIVITY OF IMIDAZO[2,1-B]THIAZOLE ACETOHYDRAZONES
ANDREANI, A
RAMBALDI, M
MASCELLANI, G
RUGARLI, P
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1987, 22 (01) : 19 - 22
[5] ANDREANI A, 1986, EUR J MED CHEM, V21, P451
[6] ANDREANI A, 1985, EUR J MED CHEM, V20, P93
[7] POTENTIAL ANTI-TUMOR AGENTS .16. IMIDAZO[2,1-B]THIAZOLES
ANDREANI, A
RAMBALDI, M
ANDREANI, F
BOSSA, R
GALATULAS, I
[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1988, 23 (04) : 385 - 389
[8] ANDREANI A, 1980, FARMACO-ED SCI, V35, P573
[9] ANDREANI A, 1980, FARMACO-ED SCI, V35, P896
[10] ANDREANI A, 1984, EUR J MED CHEM, V19, P219

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