Targeted contrast agents for magnetic resonance imaging and ultrasound

被引：176

作者：

Morawski, AM ^{[1
]}

Lanza, GA ^{[1
]}

Wickline, SA ^{[1
]}

机构：

[1] Washington Univ, Sch Med, St Louis, MO 63110 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2005年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.copbio.2004.11.001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The development of contrast agents that can be localized to a particular tissue or cellular epitope will potentially allow the noninvasive visualization and characterization of a variety of disease states. Recent advances have been made in the field of molecular imaging with magnetic resonance imaging and ultrasound and varied approaches have been devised to overcome the high background tissue signal. The types of agents and applications developed include gadolinium-conjugated targeting molecules for imaging of fibrin, superparamagnetic iron oxide particles for stem-cell tracking, multimodal perfluorocarbon nanoparticles for visualization of angiogenesis, liposomes for targeting atheroma components, and microbubbles for imaging transplant rejection.

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页码：89 / 92

页数：4

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