Chemical and functional diversity of small molecule ligands for RNA

被引：61

作者：

Hermann, T

机构：

[1] Anadys Pharmaceut Inc, Dept Computat Chem, San Diego, CA 92121 USA

[2] Anadys Pharmaceut Inc, Dept Struct & RNA Biochem, San Diego, CA 92121 USA

来源：

BIOPOLYMERS | 2003年 / 70卷 / 01期

关键词：

antibiotics; drug design; ribosome; RNA; vitamins;

D O I：

10.1002/bip.10410

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional RNAs such as ribosomal RNA and structured domains of mRNA are targets for small molecule ligands that can act as modulators of the RNA biological activity. Natural ligands for RNA display a bewildering structural and chemical complexity that has yet to be matched by synthetic RNA binders. Comparison of natural and artificial ligands for RNA may help to direct future approaches to design and synthesize potent novel scaffolds for specific recognition of RNA targets. (C) 2003 Wiley Periodicals, Inc.

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页码：4 / 18

页数：15

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