New piperazinyl polyazacyclophane scaffolds, libraries and biological activities

被引：16

作者：

An, HY ^{[1
]}

Haly, BD ^{[1
]}

Cook, PD ^{[1
]}

机构：

[1] ISIS Pharmaceut, Carlsbad, CA 92008 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(98)00424-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four novel unsymmetric piperazinyl polyazacyclophane scaffolds 1-4 were synthesized in high yields by an efficient cyclization strategy. Twenty-six libraries 12-37 (total 16000 compounds) were generated by a solution-phase combinatorial approach from 1-4 and thirty-eight functional groups. Potent antibacterial and HIV-1 tat/TAR protein-RNA disrupting activities were discovered. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2345 / 2350

页数：6

共 42 条

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