Acute modulation of cortical oscillatory activities during short trains of high-frequency repetitive transcranial magnetic stimulation of the human motor cortex: A combined EEG and TMS study

被引:93
作者
Fuggetta, Giorgio [1 ]
Pavone, Enea F. [1 ]
Fiaschi, Antonio [1 ]
Manganotti, Paolo [1 ]
机构
[1] Univ Verona, Gianbattista Rossi Hosp, Dept Neurol & Visual Sci, Sect Neurol Rehabil, I-37134 Verona, Italy
关键词
motor cortex; connectivity; oscillations; cerebral cortex; EEG-TMS combination; GABAergic modulation;
D O I
10.1002/hbm.20371
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In this study, a combined repetitive transcranial magnetic stimulation/electroencephalography (rTMS/EEG) method was used to explore the acute changes of cortical oscillatory activity induced by intermittent short trains of high-frequency (5-Hz) rTMS delivered over the left primary motor cortex (M1). We evaluated the electrophysiological reaction to magnetic stimulation during and 2-4 s after 20 trains of 20-pulses rTMS, using event-related power (ERPow) that reflects the regional oscillatory activity of neural assemblies, and event-related coherence (ERCoh) that reflects the interregional functional connectivity of oscillatory neural activity. These event-related transformations were for the upper a (10-12 Hz) and beta (18-22 Hz) frequency ranges, respectively. For the a band, threshold rTMS and subthreshold rTMS induced an ERPow increase during the trains of stimulation mainly in frontal and central regions ipsilateral to stimulation. For the P band, a similar synchronization of cortical oscillations for both rTMS intensities was seen. Moreover, subthreshold rTMS affected a-band activity more than threshold rTMS, inducing a specific ERCoh decrease over the posterior regions during the trains of stimulation. For beta band, the decrease in functional coupling was observed mainly during threshold rTMS. These findings provide a better understanding of the cortical effects of high-frequency rTMS, whereby the induction of oscillations reflects the capacity of electromagnetic pulses to alter regional and interregional synaptic transmissions of neural populations.
引用
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页码:1 / 13
页数:13
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