学术探索
学术期刊
新闻热点
数据分析
智能评审

Enantiomer separation by open-tubular liquid chromatography and electrochromatography in cellulose-coated capillaries

被引：92
作者：
Francotte, E
Jung, M
机构：
[1] Ciba, Pharmaceutical Research, K-122.P.25
来源：
CHROMATOGRAPHIA | 1996年 / 42卷 / 9-10期
关键词：
open-tubular liquid chromatography; capillary electrochromatography and electrophoresis; cellulose derivatives; chiral stationary phase (CSP); enantiomer separation;
D O I：
10.1007/BF02290286
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The feasibility of enantiomer separations by normal-phase and reversed-phase open-tubular liquid chromatography as well as by capillary electrochromatography in 50 mu m i.d. fused silica capillaries coated with cellulose derivatives is demonstrated for a number of chiral pharmaceuticals. The excellent enantioselectivity of 3,5-dimethylphenylcarbamoyl cellulose and para-methylbenzoyl cellulose has been transferred from HPLC to a miniaturized, open-tubular system. A comparison of HPLC, OTLC and CEC is made and the influence of retention and temperature on efficiency, selectivity and resolution is discussed.
引用
收藏
页码：521 / 527
页数：7
相关论文
共 38 条
1234