学术探索
学术期刊
新闻热点
数据分析
智能评审

Role of endothelin-1 in lung disease

被引：228
作者：
Fagan, KA [1 ]
McMurtry, IF [1 ]
Rodman, DM [1 ]
机构：
[1] Univ Colorado, Hlth Sci Ctr, Div Pulm Sci & Crit Care Med, Cardiovasc Pulm Res Lab, Denver, CO 80262 USA
来源：
RESPIRATORY RESEARCH | 2001年 / 2卷 / 02期
关键词：
asthma; endothelin; fibrosis; inflammation; pulmonary hypertension;
D O I：
10.1186/rr44
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Endothelin-1 (ET-1) is a 21 amino acid peptide with diverse biological activity that has been implicated in numerous diseases. ET-1 is a potent mitogen regulator of smooth muscle tone, and inflammatory mediator that may play a key role in diseases of the airways, pulmonary circulation, and inflammatory lung diseases, both acute and chronic. This review will focus on the biology of ET-1 and its role in lung disease.
引用
收藏
页码：90 / 101
页数：12
相关论文
共 175 条
  • [41] VASCULAR-RESPONSES TO ENDOTHELIN-1 FOLLOWING INHIBITION OF NITRIC-OXIDE SYNTHESIS IN THE CONSCIOUS RAT
    FILEP, JG
    FOLDESFILEP, E
    ROUSSEAU, A
    SIROIS, P
    FOURNIER, A
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1993, 110 (03) : 1213 - 1221
  • [42] Endothelin production and effects of endothelin antagonism during experimental airway inflammation
    Finsnes, F
    Skjonsberg, OH
    Tonnessen, T
    Naess, O
    Lyberg, T
    Christensen, G
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (04) : 1404 - 1412
  • [43] Increased synthesis and release of endothelin-1 during the initial phase of airway inflammation
    Finsnes, F
    Christensen, G
    Lyberg, T
    Sejersted, OM
    Skjonsberg, OH
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (05) : 1600 - 1606
  • [44] Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation
    Finsnes, F
    Skjonsberg, OH
    Lyberg, T
    Christensen, G
    [J]. EUROPEAN RESPIRATORY JOURNAL, 2000, 15 (04) : 743 - 750
  • [45] Endothelin-1 is elevated in monocrotaline pulmonary hypertension
    Frasch, HF
    Marshall, C
    Marshall, BE
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1999, 276 (02) : L304 - L310
  • [46] Plasma endothelin-1 level in chronic obstructive pulmonary disease: Relationship with natriuretic peptide
    Fujii, T
    Otsuka, T
    Tanaka, S
    Kanazawa, H
    Hirata, K
    Kohno, M
    Kurihara, N
    Yoshikawa, J
    [J]. RESPIRATION, 1999, 66 (03) : 212 - 219
  • [47] Endothelin receptor antagonists inhibit antigen-induced lung inflammation in mice
    Fujitani, Y
    Trifilieff, A
    Tsuyuki, S
    Coyle, AJ
    Bertrand, C
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1997, 155 (06) : 1890 - 1894
  • [48] ENDOTHELIN RECEPTOR SUBTYPES IN HUMAN VERSUS RABBIT PULMONARY-ARTERIES
    FUKURODA, T
    KOBAYASHI, M
    OZAKI, S
    YANO, M
    MIYAUCHI, T
    ONIZUKA, M
    SUGISHITA, Y
    GOTO, K
    NISHIKIBE, M
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 1994, 76 (05) : 1976 - 1982
  • [49] DETECTION OF ENDOTHELIN IMMUNOREACTIVITY AND MESSENGER-RNA IN PULMONARY TUMORS
    GIAID, A
    HAMID, QA
    SPRINGALL, DR
    YANAGISAWA, M
    SHINMI, O
    SAWAMURA, T
    MASAKI, T
    KIMURA, S
    CORRIN, B
    POLAK, JM
    [J]. JOURNAL OF PATHOLOGY, 1990, 162 (01) : 15 - 22
  • [50] DISTRIBUTION OF ENDOTHELIN-LIKE IMMUNOREACTIVITY AND MESSENGER-RNA IN THE DEVELOPING AND ADULT HUMAN LUNG
    GIAID, A
    POLAK, JM
    GAITONDE, V
    HAMID, QA
    MOSCOSO, G
    LEGON, S
    UWANOGHO, D
    RONCALLI, M
    SHINMI, O
    SAWAMURA, T
    KIMURA, S
    YANAGISAWA, M
    MASAKI, T
    SPRINGALL, DR
    [J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 1991, 4 (01) : 50 - 58
12345678910