Immunological update on multiple sclerosis

被引：81

作者：

Hohlfeld, R ^{[1
]}

Wekerle, H

机构：

[1] Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany

[2] Univ Munich, Klinikum Grosshadern, Inst Clin Neuroimmunol, D-8000 Munich, Germany

来源：

CURRENT OPINION IN NEUROLOGY | 2001年 / 14卷 / 03期

关键词：

D O I：

10.1097/00019052-200106000-00006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present review of the recent literature focuses on antigen-specific immune reactions in multiple sclerosis. New techniques have allowed precise quantitative analysis of the antigen-receptor repertoire of infiltrating T cells in the multiple sclerosis brain. Novel candidate autoantigens, including B-cell autoantigens, have been identified, 'Humanized' animal models allow the functional characterization of human immune molecules in vivo. Finally, several therapeutic trials have recently assessed the clinical benefit of selective immunotherapies. Curr Opin Neurol 14:299-304. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：299 / 304

页数：6

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