Immunological update on multiple sclerosis

被引：81

作者：

Hohlfeld, R ^{[1
]}

Wekerle, H

机构：

[1] Max Planck Inst Neurobiol, Dept Neuroimmunol, D-82152 Martinsried, Germany

[2] Univ Munich, Klinikum Grosshadern, Inst Clin Neuroimmunol, D-8000 Munich, Germany

来源：

CURRENT OPINION IN NEUROLOGY | 2001年 / 14卷 / 03期

关键词：

D O I：

10.1097/00019052-200106000-00006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The present review of the recent literature focuses on antigen-specific immune reactions in multiple sclerosis. New techniques have allowed precise quantitative analysis of the antigen-receptor repertoire of infiltrating T cells in the multiple sclerosis brain. Novel candidate autoantigens, including B-cell autoantigens, have been identified, 'Humanized' animal models allow the functional characterization of human immune molecules in vivo. Finally, several therapeutic trials have recently assessed the clinical benefit of selective immunotherapies. Curr Opin Neurol 14:299-304. (C) 2001 Lippincott Williams & Wilkins.

引用

页码：299 / 304

页数：6

共 60 条

[21] Myelin reactive T cells after T cell vaccination in multiple sclerosis: cytokine profile and depletion by additional immunizations [J].

Hermans, G ;

Medaer, R ;

Raus, J ;

Stinissen, P .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 102 (01) :79-84

[22] The neuroprotective effect of inflammation: implications for the therapy of multiple sclerosis [J].

Hohlfeld, R ;

Kerschensteiner, M ;

Stadelmann, C ;

Lassmann, H ;

Wekerle, H .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 107 (02) :161-166

[23] Biotechnological agents for the immunotherapy of multiple sclerosis - Principles, problems and perspectives [J].

Hohlfeld, R .

BRAIN, 1997, 120 :865-916

[24] Myelin-associated oligodendrocytic basic protein: Identification of an encephalitogenic epitope and association with multiple sclerosis [J].

Holz, A ;

Bielekova, B ;

Martin, R ;

Oldstone, MBA .

JOURNAL OF IMMUNOLOGY, 2000, 164 (02) :1103-1109

[25] Differential expression of NK T cell Vα24JαQ invariant TCR chain in the lesions of multiple sclerosis and chronic inflammatory demyelinating polyneuropathy [J].

Illés, Z ;

Kondo, T ;

Newcombe, J ;

Oka, N ;

Tabira, T ;

Yamamura, T .

JOURNAL OF IMMUNOLOGY, 2000, 164 (08) :4375-4381

[26] The structure and function of myelin oligodendrocyte glycoprotein [J].

Johns, TG ;

Bernard, CCA .

JOURNAL OF NEUROCHEMISTRY, 1999, 72 (01) :1-9

[27] Induction of a non-encephalitogenic type 2 T helper-cell autoimmune response in multiple sclerosis after administration of an altered peptide ligand in a placebo-controlled, randomized phase II trial [J].

Kappos, L ;

Comi, G ;

Panitch, H ;

Oger, J ;

Antel, J ;

Conlon, P ;

Steinman, L .

NATURE MEDICINE, 2000, 6 (10) :1176-1182

[28] HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice [J].

Kawamura, K ;

Yamamura, T ;

Yokoyama, K ;

Chui, DH ;

Fukui, Y ;

Sasazuki, T ;

Inoko, H ;

David, CS ;

Tabira, T .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (07) :977-984

[29] The central nervous sytem-specific myelin oligodendrocytic basic protein (MOBP) is encephalitogenic and a potential target antigen in multiple sclerosis (MS) [J].

Kaye, JF ;

de Rosbo, NK ;

Mendel, I ;

Flechter, S ;

Hoffman, M ;

Yust, I ;

Ben-Nun, A .

JOURNAL OF NEUROIMMUNOLOGY, 2000, 102 (02) :189-198

[30] Activated human T cells, B cells, and monocytes produce brain-derived neurotrophic factor in vitro and in inflammatory brain lesions: A neuroprotective role of inflammation? [J].

Kerschensteiner, M ;

Gallmeier, E ;

Behrens, L ;

Leal, VV ;

Misgeld, T ;

Klinkert, WEF ;

Kolbeck, R ;

Hoppe, E ;

Oropeza-Wekerle, RL ;

Bartke, I ;

Stadelmann, C ;

Lassmann, H ;

Wekerle, H ;

Hohlfeld, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :865-870

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