N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-linked nitroxides:: Potential magnetic resonance contrast agents

被引：25

作者：

Huang, Y

Nan, AJ

Rosen, GM

Winalski, CS

Schneider, E

Tsai, P

Ghandehari, H ^{[1
]}

机构：

[1] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA

[2] Sichuan W China Sch Pharm, Dept Pharmaceut Sci, Chengdu 610041, Peoples R China

[3] Univ Maryland, Inst Biotechnol, Ctr Med Biotechnol, Baltimore, MD 21201 USA

[4] Univ Maryland, Sch Pharm, Ctr Very Low Frequency EPR Imaging In Vivo Physio, Baltimore, MD 21201 USA

[5] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA

[6] SciTrials LLC, Westwood, MA 02090 USA

[7] Univ Maryland, Greenebaum Canc Ctr, Baltimore, MD 21201 USA

来源：

MACROMOLECULAR BIOSCIENCE | 2003年 / 3卷 / 11期

关键词：

biological applications of polymers; drug delivery systems; HPMA copolymers; magnetic resonance imaging; nitroxide contrast agents;

D O I：

10.1002/mabi.200350031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymer-linked nitroxides were synthesized as macromolecular contrast agents for MR imaging. Molar relaxivities of HPMA copolymer-linked nitroxides increased linearly in proportion to the number of nitroxides attached per gram of copolymer. HPMA copolymer-linked nitroxides with 15, 20 and 30 mol-% nitroxide exhibited higher relaxivities than gadolinium diethylenetriaminepentaacetic acid (Gd-DTPA). These results demonstrate the potential of HPMA copolymer-linked nitroxides as MR contrast agents for solid tumors.

引用

页码：647 / 652

页数：6

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