Functional neuroimaging with positron emission tomography

被引：37

作者：

Henry, TR

机构：

[1] Department of Neurology, Emory University School of Medicine, Atlanta, GA

[2] Department of Neurology, Emory University, Woodruff Memorial Research Building, Atlanta, GA 30322

来源：

EPILEPSIA | 1996年 / 37卷 / 12期

关键词：

positron emission tomography; neuroimaging; epilepsy;

D O I：

10.1111/j.1528-1157.1996.tb00546.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Epilepsy research using positron emission tomography (PET) has provided considerable new information about ictal and interictal dysfunctions in human epilepsy. Neuroreceptor mapping with PET ligands has revealed altered central benzodiazepine receptor and opiate receptor densities in partial epilepsies interictally, and regional increases in endogenous opioid peptide concentrations during absence seizures. Imaging of perfusion and glucose metabolism during cognitive processing has shown interictal abnormalities of regional activation in partial and generalized epilepsies. The diagnostically robust patterns of interictal glucose hypometabolism are not adequately explained by macrostructural and microstructural alterations in temporal lobe epilepsy. Current investigations of the pathophysiology of interictal hypometabolism must address ultrastructural and neurochemical factors. Clinical PET in pre surgical evaluation of medically refractory epilepsies remains an active area of research, but remarkably little antiepileptic drug research has exploited PET techniques.

引用

页码：1141 / 1154

页数：14

共 124 条

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