HIV-1 Vpu targets cell surface markers CD4 and BST-2 through distinct mechanisms

被引：35

作者：

Andrew, Amy ^{[1
]}

Strebel, Klaus ^{[1
]}

机构：

[1] NIAID, Viral Biochem Sect, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

来源：

MOLECULAR ASPECTS OF MEDICINE | 2010年 / 31卷 / 05期

关键词：

Vpu; Degradation of CD4; HIV-1; release; BST-2; beta-TrCP; VIRUS TYPE-1 VPU; PROTEIN-U VPU; SIMIAN-IMMUNODEFICIENCY-VIRUS; CLATHRIN-MEDIATED ENDOCYTOSIS; FULL-LENGTH VPU; CYTOPLASMIC DOMAIN; PARTICLE RELEASE; ENVELOPE GLYCOPROTEIN; TRANSMEMBRANE DOMAIN; ENDOPLASMIC-RETICULUM;

D O I：

10.1016/j.mam.2010.08.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Vpu is a small integral membrane protein encoded by HIV-1 and some SIV isolates. The protein is known to induce degradation of the viral receptor molecule CD4 and to enhance the release of newly formed virions from the cell surface. Vpu accomplishes these two functions through two distinct mechanisms. In the case of CD4, Vpu acts as a molecular adaptor to connect CD4 to an E3 ubiquitin ligase complex resulting in CD4 degradation by cellular proteasomes. This requires signals located in Vpu's cytoplasmic domain. Enhancement of virus release on the other hand involves the neutralization of a cellular host factor, BST-2 (also known as CD317, HM1.24, or tetherin) and requires Vpu's TM domain. The current review discusses recent advances on the role of Vpu in controlling degradation of CD4 and in regulating virus release. Published by Elsevier Ltd.

引用

页码：407 / 417

页数：11

共 121 条

[21] HIV-1 encoded virus protein U (Vpu) solution structure of the 41-62 hydrophilic region containing the phosphorylated sites Ser52 and Ser56 [J].

Coadou, GL ;

Evrard-Todeschi, N ;

Gharbi-Benarous, J ;

Benarous, R ;

Girault, JP .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2002, 30 (01) :23-40

[22] CD4 IS RETAINED IN THE ENDOPLASMIC-RETICULUM BY THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 GLYCOPROTEIN PRECURSOR [J].

CRISE, B ;

BUONOCORE, L ;

ROSE, JK .

JOURNAL OF VIROLOGY, 1990, 64 (11) :5585-5593

[23] Characterization of a novel vpu-harboring simian immunodeficiency virus from a dent's mona monkey (Cercopithecus mona denti) [J].

Dazza, MC ;

Ekwalanga, M ;

Nende, M ;

Bin Shamamba, K ;

Bitshi, P ;

Paraskevis, D ;

Saragosti, S .

JOURNAL OF VIROLOGY, 2005, 79 (13) :8560-8571

[24] Vpu Directs the Degradation of the Human Immunodeficiency Virus Restriction Factor BST-2/Tetherin via a βTrCP-Dependent Mechanism [J].

Douglas, Janet L. ;

Viswanathan, Kasinath ;

McCarroll, Matthew N. ;

Gustin, Jean K. ;

Frueh, Klaus ;

Moses, Ashlee V. .

JOURNAL OF VIROLOGY, 2009, 83 (16) :7931-7947

[25] Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment [J].

Dube, Mathieu ;

Roy, Bibhuti Bhusan ;

Guiot-Guillain, Pierre ;

Binette, Julie ;

Mercier, Johanne ;

Chiasson, Antoine ;

Cohen, Eric A. .

PLOS PATHOGENS, 2010, 6 (04) :1-19

[26] Suppression of Tetherin-Restricting Activity upon Human Immunodeficiency Virus Type 1 Particle Release Correlates with Localization of Vpu in the trans-Golgi Network [J].

Dube, Mathieu ;

Roy, Bibhuti Bhusan ;

Guiot-Guillain, Pierre ;

Mercier, Johanne ;

Binette, Julie ;

Leung, Grace ;

Cohen, Eric A. .

JOURNAL OF VIROLOGY, 2009, 83 (09) :4574-4590

[27] The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels [J].

Ewart, GD ;

Sutherland, T ;

Gage, PW ;

Cox, GB .

JOURNAL OF VIROLOGY, 1996, 70 (10) :7108-7115

[28] The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum [J].

Fang, SY ;

Ferrone, M ;

Yang, CH ;

Jensen, JP ;

Tiwari, S ;

Weissman, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (25) :14422-14427

[29]

Federau T, 1996, INT J PEPT PROT RES, V47, P297

[30] Direct Restriction of Virus Release and Incorporation of the Interferon-Induced Protein BST-2 into HIV-1 Particles [J].

Fitzpatrick, Kathleen ;

Skasko, Mark ;

Deerinck, Thomas J. ;

Crum, John ;

Ellisman, Mark H. ;

Guatelli, John .

PLOS PATHOGENS, 2010, 6 (03)

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