Homochiral porous metal-organic framework for highly enantioselective heterogeneous asymmetric catalysis

被引:1779
作者
Wu, CD [1 ]
Hu, A [1 ]
Zhang, L [1 ]
Lin, WB [1 ]
机构
[1] Univ N Carolina, Dept Chem, Chapel Hill, NC 27599 USA
关键词
D O I
10.1021/ja052431t
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A homochiral porous noninterpenetrating metal-organic framework (MOF), 1, was constructed by linking infinite 1D [Cd(μ-Cl)2]n zigzag chains with axially chiral bipyridine bridging ligands containing orthogonal secondary functional groups. The secondary chiral dihydroxy groups accessible via the large open channels in 1 were utilized to generate a heterogeneous asymmetric catalyst for the addition of diethyzinc to aromatic aldehydes to afford chiral secondary alcohols at up to 93% enantiomeric excess (ee). Control experiments with dendritic aromatic aldehydes of different sizes indicate that the heterogeneous asymmetric catalyst derived from 1 is both highly active and enantioselective as a result of the creation of readily accessible, uniform active catalyst sites inside the porous MOF. Copyright © 2005 American Chemical Society.
引用
收藏
页码:8940 / 8941
页数:2
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