Novel findings in inhibition of mast cell-dependent immediate-type cutaneous reactions by Gahmi-Shini-San

被引：11

作者：

Hong, SH

Kim, MS

Lee, JY

Hwang, CY

Baek, SH

Han, DS

Jung, WY

Seo, SB

Kajiuchi, T

Kim, HM ^{[1
]}

机构：

[1] Wonkwang Univ, Dept Oriental Pharm, Coll Pharm, Iksan 570749, Chonbuk, South Korea

[2] Wonkwang Univ, Ctr Oriental Med Sci, Iksan 570749, Chonbuk, South Korea

[3] Wonkwang Univ, Coll Oriental Med, Iksan 570749, Chonbuk, South Korea

[4] Wonkwang Univ, Dept Nat Prod, Profess Grad Sch Oriental Med, Iksan 570749, Chonbuk, South Korea

[5] Wonkwang Univ, Dept Oral Anat, Sch Dent, Iksan 570749, Chonbuk, South Korea

[6] JAKWANG Co Ltd, Ansung 456380, Kyonggi, South Korea

[7] Tokyo Inst Technol, Dept Int Dev Engn, Meguro Ku, Tokyo 1528552, Japan

来源：

CLINICA CHIMICA ACTA | 2001年 / 309卷 / 01期

关键词：

Gahmi-Shini-San; rat peritoneal mast cells; alcian blue/nuclear fast red staining; ear swelling response; passive cutaneous anaphylaxis;

D O I：

10.1016/S0009-8981(01)00532-0

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

This report describes an inhibitory effect of Gahmi-Shini-San (GSS) on mast cell-mediated immediate-type allergic reactions. GSS is an Oriental herbal medication, which has been successfully used in Korea for the treatment of allergic disorders, mainly skin anaphylactic diseases. GSS inhibited the ear swelling response induced by intradermal injection of compound 48/80 in a mouse model on a concentration-dependent basis. The mast cells in mouse ear tissue were stained by alcian blue/nuclear fast led. GSS significantly inhibited the compound 48/80-induced degranulation from mast cells in ear tissue. GSS dose-dependently inhibited the histamine release from the rat peritoneal mast cells by compound 48/80. We also studied the effect of GSS on mast cell-dependent passive cutaneous anaphylaxis activated by dinitrophenyl IgE antibody. GSS showed inhibition of passive cutaneous anaphylaxis following oral administration. These results indicated that GSS has inhibitory effect on mast cell-dependent immediate type cutaneous reactions. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：85 / 90

页数：6