The intracellular domain of Notch ligand Delta1 induces cell growth arrest

被引：48

作者：

Kolev, V ^{[1
]}

Kacer, D ^{[1
]}

Trifonova, R ^{[1
]}

Small, D ^{[1
]}

Duarte, M ^{[1
]}

Soldi, R ^{[1
]}

Graziani, I ^{[1
]}

Sideleva, O ^{[1
]}

Larman, B ^{[1
]}

Maciag, T ^{[1
]}

Prudovsky, I ^{[1
]}

机构：

[1] Maine Med Ctr, Res Inst, Ctr Mol Med, Scarborough, ME 04074 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 25期

关键词：

Notch; delta intracellular domain; p21; DNA synthesis; senescence;

D O I：

10.1016/j.febslet.2005.09.042

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notch signaling involves proteolytic cleavage of the transmembrane Notch receptor after binding to its transmembrane ligands, Delta or Jagged; and the resultant soluble intracellular domain of Notch stimulates a cascade of transcriptional events. The Delta1 ligand also undergoes proteolytic cleavage upon Notch binding, resulting in the production of a free intracellular domain. We demonstrate that the expression of the intracellular domain of Delta1 results in a non-proliferating senescent-like cell phenotype which is dependent on the expression of the cell cycle inhibitor, p21, and is abolished by co-expression of constitutively active Notch1. These data suggest a new intracellular role for Delta1. (c) 2005 Published by Elsevier B.V.

引用

页码：5798 / 5802

页数：5

共 24 条

[21] Soluble jagged 1 represses the function of its transmembrane form to induce the formation of the Src-dependent chord-like phenotype [J].

Small, D ;

Kovalenko, D ;

Kacer, D ;

Liaw, L ;

Landriscina, M ;

Di Serio, C ;

Prudovsky, I ;

Maciag, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (34) :32022-32030

[22] The non-transmembrane form of Delta1, but not of Jagged1, induces normal migratory behavior accompanied by fibroblast growth factor receptor 1-dependent transformation [J].

Trifonova, R ;

Small, D ;

Kacer, D ;

Kovalenko, D ;

Kolev, V ;

Mandinova, A ;

Soldi, R ;

Liaw, L ;

Prudovsky, I ;

Maciag, T .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (14) :13285-13288

[23] The ins and outs of Notch signaling [J].

Weinmaster, G .

MOLECULAR AND CELLULAR NEUROSCIENCE, 1997, 9 (02) :91-102

[24]

WESSENDORF JHM, 1993, J BIOL CHEM, V268, P22100

← 1 2 3 →