Development of cellular therapy for the treatment of stress urinary incontinence

被引：31

作者：

Wang, Hung-Jen ^{[2
]}

Chuang, Yao-Chi ^{[2
]}

Chancellor, Michael B. ^{[1
]}

机构：

[1] Oakland Univ, William Beaumont Sch Med, Dept Urol, Royal Oak, MI 48073 USA

[2] Chang Gung Univ, Chang Gung Mem Hosp, Kaohsiung Med Ctr, Dept Urol,Coll Med, Kaohsiung, Taiwan

来源：

INTERNATIONAL UROGYNECOLOGY JOURNAL | 2011年 / 22卷 / 09期

关键词：

Mesenchymal stem cells; Muscle-derived stem cells; Stem cell therapy; Stress urinary incontinence; INTRINSIC SPHINCTER DEFICIENCY; MESENCHYMAL STEM-CELLS; LEAK POINT PRESSURE; FREE VAGINAL TAPE; HUMAN ADIPOSE-TISSUE; URETHRAL CLOSURE MECHANISMS; RANDOMIZED CONTROLLED-TRIAL; MUSCLE-DERIVED CELLS; BONE-MARROW; RAT MODEL;

D O I：

10.1007/s00192-011-1432-1

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Stress urinary incontinence (SUI) is highly prevalent and associated with a reduced quality of life. An intact rhabdosphincter at the mid-urethra is mandatory to maintain urinary continence. Adult stem cell injection therapy for the regenerative repair of an impaired sphincter is currently at the forefront of incontinence research. The implanted cells will fuse with muscle and release trophic factors promoting nerve and muscle integration. Hereby, we review the use of mesenchymal stem cell therapy for SUI and the experience with the development of muscle-derived stem cells.

引用

页码：1075 / 1083

页数：9

共 79 条

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