Results of a new rapid D-dimer assay (Cardiac D-dimer) in the diagnosis of deep vein thrombosis

被引:34
作者
Bucek, RA
Quehenberger, P
Feliks, I
Handler, S
Reiter, M
Minar, E
机构
[1] Univ Vienna, Gen Hosp, Clin Internal Med 2, Dept Angiol, A-1090 Vienna, Austria
[2] Gen Hosp, Univ Clin, Dept Lab Med, Vienna, Austria
关键词
deep vein thrombosis; D-dimer; hemostaseology; angiology; fibrinolysis; fibrin degradation products;
D O I
10.1016/S0049-3848(00)00367-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The objective was to evaluate the accuracy of a new full blood rapid D-dimer assay in the diagnosis of suspected deep vein thrombosis (DVT). In 100 consecutive patients with suspected DVT, clinical probability was staged according to a pretest score proposed by Wells. For the determination of plasma D-dimer, heparin and citrate blood samples were drawn, and Cardiac D-dimer, STA-LIA, and Tina-quant tests were performed. Final diagnosis was confirmed either by duplex sonography or ascending venography. DVT was diagnosed in 37%, thrombophlebitis in 10%, and no venous thromboembolism was diagnosed in 52%. In 2% pulmonary embolism was detected and one patient was dismissed before final diagnosis. Cardiac D-dimer assay from citrate tubes showed a sensitivity of 88.6%, a specificity of 54%, a positive predictive value of 57.4%, and a negative predictive value of 87.1%. Nearly identical results were observed with heparin tubes. Corresponding results were 88.6%, 48%, 52.5%, and 85.7% for STA-LIA and 88.6%, 46%, 53.4%, and 85.2% for Tina-quant, respectively. In conclusion, we can say that Cardiac D-dimer is a rapid, whole blood assay with a great potential for clinical use. It can help in diagnosing DVT from citrate as well as heparin tubes with comparable sensitivity, specificity, positive and negative predictive values as STA-LIA and Tina-quant tests. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:17 / 23
页数:7
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