Transcription factories: genetic programming in three dimensions

被引：111

作者：

Edelman, Lucas Brandon ^{[1
,2
]}

Fraser, Peter ^{[1
]}

机构：

[1] Babraham Inst, Nucl Dynam Lab, Cambridge CB22 3AT, England

[2] Univ Cambridge, Kings Coll, Cambridge CB2 1ST, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2012年 / 22卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

RNA-POLYMERASE-II; ORGANIZATION; SITES; VISUALIZATION; MOUSE; MICE; CELL;

D O I：

10.1016/j.gde.2012.01.010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Among the most intensively studied systems in molecular biology is the eukaryotic transcriptional apparatus, which expresses genes in a regulated manner across hundreds of different cell types. Several studies over the past few years have added weight to the concept that transcription takes place within discrete 'transcription factories' assembled inside the cell nucleus. These studies apply innovative technical approaches to gain insights into the molecular constituents,. dynamical behaviour and organizational regulators of transcription factories, providing exciting insights into the spatial dimension of transcriptional control.

引用

页码：110 / 114

页数：5

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