Biosynthesis of the vancomycin group of antibiotics:: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine

被引：36

作者：

Li, TL ^{[1
]}

Choroba, OW ^{[1
]}

Hong, H ^{[1
]}

Williams, DH ^{[1
]}

Spencer, JB ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 20期

关键词：

D O I：

10.1039/b106638b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

3,5-dihydroxyphenylacetate, a precursor for the non-proteinogenic amino acid 3,5-dihydroxyphenylglycine occurring in glycopeptide antibiotics, is determined to be catalysed by a type III polyketide synthase using malonyl-CoA as a starter unit.

引用

页码：2156 / 2157

页数：2

共 11 条

[1] Biosynthesis of the vancomycin group of antibiotics:: Involvement of an unusual dioxygenase in the pathway to (S)-4-hydroxyphenylglycine [J].

Choroba, OW ;

Williams, DH ;

Spencer, JB .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2000, 122 (22) :5389-5390

[2] Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis [J].

Ferrer, JL ;

Jez, JM ;

Bowman, ME ;

Dixon, RA ;

Noel, JP .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (08) :775-784

[3] INVITRO EFFECTS OF VANCOMYCIN, RIFAMPICIN, AND FUSIDIC ACID, ALONE AND IN COMBINATION, AGAINST METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS [J].

FOLDES, M ;

MUNRO, R ;

SORRELL, TC ;

SHANKER, S ;

TOOHEY, M .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1983, 11 (01) :21-26

[4] A new pathway for polyketide synthesis in microorganisms [J].

Funa, N ;

Ohnishi, Y ;

Fujii, I ;

Shibuya, M ;

Ebizuka, Y ;

Horinouchi, S .

NATURE, 1999, 400 (6747) :897-899

[5] ON THE BIOSYNTHESIS OF THE ANTIBIOTIC VANCOMYCIN [J].

HAMMOND, SJ ;

WILLIAMSON, MP ;

WILLIAMS, DH ;

BOECK, LD ;

MARCONI, GG .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1982, (06) :344-346

[6] Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics [J].

Hubbard, BK ;

Thomas, MG ;

Walsh, CT .

CHEMISTRY & BIOLOGY, 2000, 7 (12) :931-942

[7] THE SYNTHESIS OF CHIRAL MALONATES AND THE DETERMINATION OF THEIR CHIRALITY USING FATTY-ACID SYNTHASE AND MASS-SPECTROMETRY [J].

JORDAN, PM ;

SPENCER, JB ;

CORINA, DL .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1986, (12) :911-913

[8] Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics [J].

Li, TL ;

Choroba, OW ;

Charles, EH ;

Sandercock, AM ;

Williams, DH ;

Spencer, JB .

CHEMICAL COMMUNICATIONS, 2001, (18) :1752-1753

[9]

Sandercock AM, 2001, CHEM COMMUN, P1252, DOI 10.1039/b103668h

[10] Probing plant polyketide biosynthesis [J].

Schröder, J .

NATURE STRUCTURAL BIOLOGY, 1999, 6 (08) :714-716

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