Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues

被引：68

作者：

Bronckers, ALJJ

Engelse, MA

Cavender, A

Gaikwad, J

D'Souza, RN

机构：

[1] Free Univ Amsterdam, ACTA, Dept Oral Cell Biol, NL-1081 BT Amsterdam, Netherlands

[2] Univ Texas, Hlth Sci Ctr, Dept Orthodont, Dent Branch, Houston, TX USA

[3] Univ Amsterdam, Acad Med Ctr, Dept Biochem, NL-1105 AZ Amsterdam, Netherlands

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 101卷 / 1-2期

关键词：

transcription factor; cleidocranial dysplasia; osteoblasts; odontoblasts; ameloblasts; cementoblasts; periodontal ligament;

D O I：

10.1016/S0925-4773(00)00562-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cbfa1 (core binding factor alpha 1) is a transcription factor that is a key determinant of the osteoblastic lineage. Recent data showed that Cbfa1 is also highly expressed in early stages of tooth development and is involved in crown morphogenesis and cytodifferentiation of odontoblasts. Here we report the mRNA expression and protein localization of Cbfa1 in the mouse dentition in (later) stages of crown and root development. In addition to osteoblasts, osteocytes. chondrocytes. odontoblasts. dental follicle cells, cementoblasts and periodontal ligament cells, we report also Cbfa1 expression in dental epithelial cells (secretory and maturation ameloblasts) and several non-mineralizing cell types (hair follicles, ducts of salivary glands, and junctional epithelium of the gingiva). (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：255 / 258

页数：4

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