Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages

被引：39

作者：

Kotrange, Sheetal ^{[1
,2
]}

Kopp, Benjamin ^{[3
]}

Akhter, Anwari ^{[1
,2
]}

Abdelaziz, Dalia ^{[1
,2
]}

Abu Khweek, Arwa ^{[1
,2
]}

Caution, Kyle ^{[1
,2
]}

Abdulrahman, Basant ^{[1
,2
]}

Wewers, Mark D. ^{[1
,2
]}

McCoy, Karen ^{[3
]}

Marsh, Clay ^{[1
,2
]}

Loutet, Slade A. ^{[4
]}

Ortega, Ximena ^{[4
]}

Valvano, Miguel A. ^{[4
]}

Amer, Amal O. ^{[1
,2
]}

机构：

[1] Ohio State Univ, Div Pulm Allergy Crit Care & Sleep Med, Ctr Microbial Interface Biol, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Internal Med, Columbus, OH 43210 USA

[3] Nationwide Childrens Hosp, Div Pediat Pulmonol, Columbus, OH USA

[4] Univ Western Ontario, Dept Microbiol & Immunol, Ctr Human Immunol, London, ON, Canada

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2011年 / 89卷 / 03期

关键词：

cystic fibrosis transmembrane conductance regulator; Toll-like receptors; NOD-like receptors; CYSTIC-FIBROSIS; CEPACIA COMPLEX; INTRACELLULAR SURVIVAL; PSEUDOMONAS-CEPACIA; CORE-OLIGOSACCHARIDE; STRAIN J2315; LIPOPOLYSACCHARIDE; INFLAMMATION; ACTIVATION; EXPRESSION;

D O I：

10.1189/jlb.0910513

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Burkholderia cenocepacia infections in CF patients involve heightened inflammation, fatal sepsis, and high antibiotic resistance. Proinflammatory IL-1 beta secretion is important in airway inflammation and tissue damage. However, little is known about this pathway in macrophages upon B. cenocepacia infection. We report here that murine macrophages infected with B. cenocepacia K56-2 produce proinflammatory cytokine IL-1 beta in a TLR4 and caspase-1-mediated manner. We also determined that the OPS (O antigen) of B. cenocepacia LPS contributes to IL-1 beta production and pyroptotic cell death. Furthermore, we showed that the malfunction of the CFTR channel augmented IL-1 beta production upon B. cenocepacia infection of murine macrophages. Taken together, we identified eukaryotic and bacterial factors that contribute to inflammation during B. cenocepacia infection, which may aid in the design of novel approaches to control pulmonary inflammation. J. Leukoc. Biol. 89: 481-488; 2011.

引用

页码：481 / 488

页数：8

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