Presence of three recurrent chromosomal rearrangements, t(2;3)(p12;q37), del(8)(q24), and t(14;18), in an acute lymphoblastic leukemia

被引：15

作者：

Berger, R ^{[1
]}

Flexor, M ^{[1
]}

LeConiat, M ^{[1
]}

Larsen, CJ ^{[1
]}

机构：

[1] INST GENET MOLEC, INSERM U301, F-75010 PARIS, FRANCE

来源：

CANCER GENETICS AND CYTOGENETICS | 1996年 / 86卷 / 01期

关键词：

D O I：

10.1016/0165-4608(95)00177-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A complex chromosomal abnormality associating three recurrent rearrangements, t(2;3) (p12;q37), del(8)(q24), and t(14;18)(q32;q21), was detected in a patient with acute lymphoblastic leukemia of the Burkitt type. Southern blot studies showed rearrangements of MYC, BCL2, and J(H) genes, thus confirming the cytogenetic data. However, no rearrangement of the LAZ3/BCL6 gene, normally localized on band 3q27, could be detected. The simultaneous presence of three recurrent rearrangements specific for lymphoid malignancies addresses the question of their timing in the malignant process and the prognostic significance of the association of such anomalies.

引用

页码：76 / 79

页数：4

共 27 条

[1] VARIANT T(2-18) TRANSLOCATION IN A BURKITT CONVERSION OF FOLLICULAR LYMPHOMA [J].