Size control goes global

被引:57
作者
Cook, Mike
Tyers, Mike
机构
[1] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[2] Univ Toronto, Dept Med Genet & Microbiol, Toronto, ON M5S 1A8, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1016/j.copbio.2007.07.006
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The size of cells, tissues and organisms is a fundamental yet poorly understood attribute of biological systems. Traditional difficulties in interrogating the basis for size regulation have been surmounted by recent systematic phenotypic analyses. Genome-wide size screens in yeast suggest that ribosome biogenesis rate dictates cell size thresholds, whereas analogous RNAi-based size screens in metazoans cells reveal further connections between cell size and translation, as well as myriad other pathways. Sophisticated genetic screens in flies have delineated the new Hippo-signalling pathway that controls tissue and organ size. While the plethora of genes that alter size phenotypes at present defies a unified model, systems-level analysis suggests many new inroads into the longstanding enigma of size control.
引用
收藏
页码:341 / 350
页数:10
相关论文
共 85 条
[41]   Shar-pei mediates cell proliferation arrest during imaginal disc growth in Drosophila [J].
Kango-Singh, M ;
Nolo, R ;
Tao, C ;
Verstreken, P ;
Hiesinger, PR ;
Bellen, HJ ;
Halder, G .
DEVELOPMENT, 2002, 129 (24) :5719-5730
[42]   COORDINATE CONTROL OF SYNTHESES OF RIBOSOMAL RIBONUCLEIC-ACID AND RIBOSOMAL-PROTEINS DURING NUTRITIONAL SHIFT-UP IN SACCHAROMYCES-CEREVISIAE [J].
KIEF, DR ;
WARNER, JR .
MOLECULAR AND CELLULAR BIOLOGY, 1981, 1 (11) :1007-1015
[43]  
Kiger A A, 2003, J Biol, V2, P27, DOI 10.1186/1475-4924-2-27
[45]   Control of cell proliferation and apoptosis by Mob as tumor suppressor, Mats [J].
Lai, ZC ;
Wei, XM ;
Shimizu, T ;
Ramos, E ;
Rohrbaugh, M ;
Nikolaidis, N ;
Ho, LL ;
Li, Y .
CELL, 2005, 120 (05) :675-685
[46]   Structural analysis of Drosophila merlin reveals functional domains important for growth control and subcellular localization [J].
LaJeunesse, DR ;
McCartney, BM ;
Fehon, RG .
JOURNAL OF CELL BIOLOGY, 1998, 141 (07) :1589-1599
[47]   NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions [J].
Lallemand, D ;
Curto, M ;
Saotome, I ;
Giovannini, M ;
McClatchey, AI .
GENES & DEVELOPMENT, 2003, 17 (09) :1090-1100
[48]   Controlling the size of organs and organisms [J].
Leevers, SJ ;
McNeill, H .
CURRENT OPINION IN CELL BIOLOGY, 2005, 17 (06) :604-609
[49]   Regulation of growth by ploidy in Caenorhabditis elegans [J].
Lozano, E ;
Sáez, AG ;
Flemming, AJ ;
Cunha, A ;
Leroi, AM .
CURRENT BIOLOGY, 2006, 16 (05) :493-498
[50]   Dachs:: an unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila [J].
Mao, Yaopan ;
Rauskolb, Cordelia ;
Cho, Eunjoo ;
Hu, Wei-Li ;
Hayter, Heather ;
Minihan, Ginny ;
Katz, Flora N. ;
Irvine, Kenneth D. .
DEVELOPMENT, 2006, 133 (13) :2539-2551