Synthesis of a tripeptide derivative containing the Phe-Arg hydroxyethylene dipeptide isostere

被引：29

作者：

Brewer, M

Rich, DH

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

[2] Univ Wisconsin, Sch Pharm, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 06期

关键词：

D O I：

10.1021/ol015612i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The protected hydroxyethylene dipeptide isostere of Phe-Arg and the tripeptide derivative 1 were synthesized as components of potential peptidase inhibitors. Key to the success of these syntheses is selective rhodium-catalyzed hydroboration in the presence of a readily reduced lactone, A convenient one-pot conversion of azides to diprotected guanidines was developed on the basis of the Staudinger reaction.

引用

页码：945 / 948

页数：4

共 27 条

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