Temporal and epigenetic regulation of neurodevelopmental plasticity

被引:22
作者
Allen, Nicholas D. [1 ]
机构
[1] Cardiff Univ, Sch Biosci, Cardiff CF10 3US, Wales
基金
英国医学研究理事会;
关键词
neural stem cell; progenitor; development; plasticity; differentiation; epigenetic;
D O I
10.1098/rstb.2006.2010
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The anticipated therapeutic uses of neural stem cells depend on their ability to retain a certain level of developmental plasticity. In particular, cells must respond to developmental manipulations designed to specify precise neural fates. Studies in vivo and in vitro have shown that the developmental potential of neural progenitor cells changes and becomes progressively restricted with time. For in vitro cultured neural progenitors, it is those derived from embryonic stem cells that exhibit the greatest developmental potential. It is clear that both extrinsic and intrinsic mechanisms determine the developmental potential of neural progenitors and that epigenetic, or chromatin structural, changes regulate and coordinate hierarchical changes in fate-determining gene expression. Here, we review the temporal changes in developmental plasticity of neural progenitor cells and discuss the epigenetic mechanisms that underpin these changes. We propose that understanding the processes of epigenetic programming within the neural lineage is likely to lead to the development of more rationale strategies for cell reprogramming that may be used to expand the developmental potential of otherwise restricted progenitor populations.
引用
收藏
页码:23 / 38
页数:16
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