H3K27 demethylases, at long last

被引：253

作者：

Swigut, Tomek

Wysocka, Joanna ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Dev Biol, Stanford, CA 94305 USA

来源：

CELL | 2007年 / 131卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.09.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Methylation of lysine 27 on histone H3 ( H3K27me) by the Polycomb complex (PRC2) proteins is associated with gene silencing in many developmental processes. A cluster of recent papers ( Agger et al., 2007; De Santa et al., 2007; Lan et al., 2007; Lee et al., 2007) identify the JmjC-domain proteins UTX and JMJD3 as H3K27-specific demethylases that remove this methyl mark, enabling the activation of genes involved in animal body patterning and the inflammatory response.

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页码：29 / 32

页数：4

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