Endocytosis proteins and cancer: a potential link?

被引：82

作者：

Floyd, S

De Camilli, P

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(98)01316-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. In addition, abnormal expression or mutation of some endocytosis proteins has been reported in human cancers. This article discusses these observations and elaborates the potential mechanisms by which the abnormal expression of endocytosis proteins might participate in the biology of cancer.

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页码：299 / 301

页数：3

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共 36 条

[1] NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion [J].

Barth, AIM ;

Pollack, AL ;

Altschuler, Y ;

Mostov, KE ;

Nelson, WJ .

JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :693-706

[2]

BERNARD OA, 1994, ONCOGENE, V9, P1039

[3] MOLECULAR-BASIS OF 11Q23 REARRANGEMENTS IN HEMATOPOIETIC MALIGNANT PROLIFERATIONS [J].

BERNARD, OA ;

BERGER, R .

GENES CHROMOSOMES & CANCER, 1995, 13 (02) :75-85

[4] An MII-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes [J].

Corral, J ;

Lavenir, I ;

Impey, H ;

Warren, AJ ;

Forster, A ;

Larson, TA ;

Bell, S ;

McKenzie, ANJ ;

King, G ;

Rabbitts, TH .

CELL, 1996, 85 (06) :853-861

[5] Synaptic vesicle endocytosis [J].

Cremona, O ;

DeCamilli, P .

CURRENT OPINION IN NEUROBIOLOGY, 1997, 7 (03) :323-330

[6] YEAST MUTANT AFFECTED FOR VIABILITY UPON NUTRIENT STARVATION - CHARACTERIZATION AND CLONING OF THE RVS161 GENE [J].

CROUZET, M ;

URDACI, M ;

DULAU, L ;

AIGLE, M .

YEAST, 1991, 7 (07) :727-743

[7] THE SYNAPTIC VESICLE-ASSOCIATED PROTEIN AMPHIPHYSIN IS THE 128-KD AUTOANTIGEN OF STIFF-MAN SYNDROME WITH BREAST-CANCER [J].

DECAMILLI, P ;

THOMAS, A ;

COFIELL, R ;

FOLLI, F ;

LICHTE, B ;

PICCOLO, G ;

MEINCK, HM ;

AUSTONI, M ;

FASSETTA, G ;

BOTTAZZO, G ;

BATES, D ;

CARTLIDGE, N ;

SOLIMENA, M ;

KILIMANN, MW .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (06) :2219-2223

[8] A TRITHORAX-LIKE GENE IS INTERRUPTED BY CHROMOSOME 11Q23 TRANSLOCATIONS IN ACUTE LEUKEMIAS [J].

DJABALI, M ;

SELLERI, L ;

PARRY, P ;

BOWER, M ;

YOUNG, BD ;

EVANS, GA .

NATURE GENETICS, 1992, 2 (02) :113-118

[9] The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family [J].

Dreyling, MH ;

MartinezCliment, JA ;

Zheng, M ;

Mao, J ;

Rowley, JD ;

Bohlander, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (10) :4804-4809

[10] Antiamphiphysin antibodies with small-cell lung carcinoma and paraneoplastic encephalomyelitis [J].

Dropcho, EJ .

ANNALS OF NEUROLOGY, 1996, 39 (05) :659-667

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