Endocytosis proteins and cancer: a potential link?

被引：82

作者：

Floyd, S

De Camilli, P

机构：

[1] Yale Univ, Sch Med, Howard Hughes Med Inst, New Haven, CT 06510 USA

[2] Yale Univ, Sch Med, Dept Cell Biol, New Haven, CT 06510 USA

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 08期

关键词：

D O I：

10.1016/S0962-8924(98)01316-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have shown that a variety of proteins participate with clathrin and clathrin adaptors in receptor-mediated endocytosis. The genes encoding some of these proteins are targets of chromosomal rearrangements in human haematopoietic malignancies. In addition, abnormal expression or mutation of some endocytosis proteins has been reported in human cancers. This article discusses these observations and elaborates the potential mechanisms by which the abnormal expression of endocytosis proteins might participate in the biology of cancer.

引用

收藏

页码：299 / 301

页数：3

相关论文

共 36 条

[31] Clathrin-coated vesicle formation and protein sorting: An integrated process [J].

Schmid, SL .

ANNUAL REVIEW OF BIOCHEMISTRY, 1997, 66 :511-548

[32] EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia [J].

So, CW ;

Caldas, C ;

Liu, MM ;

Chen, SJ ;

Huang, QH ;

Gu, LJ ;

Sham, MH ;

Wiedemann, LM ;

Chan, LC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2563-2568

[33] SUBMEMBRANOUS JUNCTIONAL PLAQUE PROTEINS INCLUDE POTENTIAL TUMOR-SUPPRESSOR MOLECULES [J].

TSUKITA, S ;

ITOH, M ;

NAGAFUCHI, A ;

YONEMURA, S ;

TSUKITA, S .

JOURNAL OF CELL BIOLOGY, 1993, 123 (05) :1049-1053

[34] Control of EGF receptor signaling by clathrin-mediated endocytosis [J].

Vieira, AV ;

Lamaze, C ;

Schmid, SL .

SCIENCE, 1996, 274 (5295) :2086-2089

[35] The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis [J].

Xiao, GH ;

Shoarinejad, F ;

Jin, F ;

Golemis, EA ;

Yeung, RS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (10) :6097-6100

[36] IDENTIFICATION OF A GENE, MLL, THAT SPANS THE BREAKPOINT IN 11Q23 TRANSLOCATIONS ASSOCIATED WITH HUMAN LEUKEMIAS [J].

ZIEMINVANDERPOEL, S ;

MCCABE, NR ;

GILL, HJ ;

ESPINOSA, R ;

PATEL, Y ;

HARDEN, A ;

RUBINELLI, P ;

SMITH, SD ;

LEBEAU, MM ;

ROWLEY, JD ;

DIAZ, MO .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (23) :10735-10739

← 1 2 3 4 →