Efficient total synthesis of 5-oxo-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid (5-oxo-ETE), a potent proinflammatory autacoid

被引：6

作者：

Mohapatra, S

Capdevila, JH

Murphy, RC

Hevko, JM

Falck, JR ^{[1
]}

机构：

[1] Univ Texas, SW Med Ctr, Dept Biochem, Dallas, TX 75390 USA

[2] Vanderbilt Univ, Sch Med, Dept Med, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Sch Med, Dept Biochem, Nashville, TN 37232 USA

[4] Natl Jewish Ctr Immunol & Resp Med, Dept Pediat, Denver, CO 80206 USA

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 25期

关键词：

eicosanoids; aldol reactions; biologically active compounds; hydrogenation; metabolites;

D O I：

10.1016/S0040-4039(01)00668-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title eicosanoid was prepared in good overall yield via a convergent aldol strategy that obviates the need for HPLC separation of olefinic isomers. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：4109 / 4110

页数：2

共 18 条

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