Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample

被引:82
作者
Al-Attar, Salam A. [1 ]
Pollex, Rebecca L. [1 ]
Ban, Matthew R. [1 ]
Young, T. Kue [2 ]
Bjerregaard, Peter [3 ]
Anand, Sonia S. [4 ]
Yusuf, Salim [4 ]
Zinman, Bernard [5 ,6 ]
Harris, Stewart B. [7 ]
Hanley, Anthony J. G. [5 ,6 ,8 ]
Connelly, Philip W. [9 ,10 ]
Huff, Murray W. [11 ]
Hegele, Robert A. [1 ,11 ]
机构
[1] Robarts Res Inst, Vasc Biol Res Grp, London, ON N6A 5C1, Canada
[2] Univ Toronto, Dept Publ Hlth Sci, Toronto, ON M5S 1A1, Canada
[3] Natl Inst Publ Hlth, Copenhagen, Denmark
[4] McMaster Univ, Populat Hlth Res Inst, Hamilton, ON, Canada
[5] Univ Toronto, Dept Med, Toronto, ON, Canada
[6] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada
[7] Univ Western Ontario, Thames Valley Family Practice Res Unit, London, ON, Canada
[8] Univ Toronto, Dept Nutr Sci, Toronto, ON, Canada
[9] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[10] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada
[11] Univ Western Ontario, Schulich Sch Med & Dent, London, ON, Canada
基金
加拿大健康研究院;
关键词
D O I
10.1186/1475-2840-7-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: The rs9939609 T > A single-nucleotide polymorphism ( SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. Methods: The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions. Results: Carriers of >= 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes. Conclusion: Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples.
引用
收藏
页数:6
相关论文
共 17 条
[1]   Metabolic syndrome - a new world-wide definition. A consensus statement from the international diabetes federation [J].
Alberti, KGMM ;
Zimmet, P ;
Shaw, J .
DIABETIC MEDICINE, 2006, 23 (05) :469-480
[2]  
Anand SS, 1998, CAN J CARDIOL, V14, P1349
[3]  
[Anonymous], INT J CIRCUMPOLAR HL
[4]   Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[5]   Association study designs for complex diseases [J].
Cardon, LR ;
Bell, JI .
NATURE REVIEWS GENETICS, 2001, 2 (02) :91-99
[6]   Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) [J].
Cleeman, JI ;
Grundy, SM ;
Becker, D ;
Clark, LT ;
Cooper, RS ;
Denke, MA ;
Howard, WJ ;
Hunninghake, DB ;
Illingworth, DR ;
Luepker, RV ;
McBride, P ;
McKenney, JM ;
Pasternak, RC ;
Stone, NJ ;
Van Horn, L ;
Brewer, HB ;
Ernst, ND ;
Gordon, D ;
Levy, D ;
Rifkind, B ;
Rossouw, JE ;
Savage, P ;
Haffner, SM ;
Orloff, DG ;
Proschan, MA ;
Schwartz, JS ;
Sempos, CT ;
Shero, ST ;
Murray, EZ .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (19) :2486-2497
[7]   The metabolic syndrome [J].
Eckel, RH ;
Grundy, SM ;
Zimmet, PZ .
LANCET, 2005, 365 (9468) :1415-1428
[8]   A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].
Frayling, Timothy M. ;
Timpson, Nicholas J. ;
Weedon, Michael N. ;
Zeggini, Eleftheria ;
Freathy, Rachel M. ;
Lindgren, Cecilia M. ;
Perry, John R. B. ;
Elliott, Katherine S. ;
Lango, Hana ;
Rayner, Nigel W. ;
Shields, Beverley ;
Harries, Lorna W. ;
Barrett, Jeffrey C. ;
Ellard, Sian ;
Groves, Christopher J. ;
Knight, Bridget ;
Patch, Ann-Marie ;
Ness, Andrew R. ;
Ebrahim, Shah ;
Lawlor, Debbie A. ;
Ring, Susan M. ;
Ben-Shlomo, Yoav ;
Jarvelin, Marjo-Riitta ;
Sovio, Ulla ;
Bennett, Amanda J. ;
Melzer, David ;
Ferrucci, Luigi ;
Loos, Ruth J. F. ;
Barroso, Ines ;
Wareham, Nicholas J. ;
Karpe, Fredrik ;
Owen, Katharine R. ;
Cardon, Lon R. ;
Walker, Mark ;
Hitman, Graham A. ;
Palmer, Colin N. A. ;
Doney, Alex S. F. ;
Morris, Andrew D. ;
Smith, George Davey ;
Hattersley, Andrew T. ;
McCarthy, Mark I. .
SCIENCE, 2007, 316 (5826) :889-894
[9]   The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase [J].
Gerken, Thomas ;
Girard, Christophe A. ;
Tung, Yi-Chun Loraine ;
Webby, Celia J. ;
Saudek, Vladimir ;
Hewitson, Kirsty S. ;
Yeo, Giles S. H. ;
McDonough, Michael A. ;
Cunliffe, Sharon ;
McNeill, Luke A. ;
Galvanovskis, Juris ;
Rorsman, Patrik ;
Robins, Peter ;
Prieur, Xavier ;
Coll, Anthony P. ;
Ma, Marcella ;
Jovanovic, Zorica ;
Farooqi, I. Sadaf ;
Sedgwick, Barbara ;
Barroso, Ines ;
Lindahl, Tomas ;
Ponting, Chris P. ;
Ashcroft, Frances M. ;
O'Rahilly, Stephen ;
Schofield, Christopher J. .
SCIENCE, 2007, 318 (5855) :1469-1472
[10]  
Groop L, 2000, BRIT J NUTR, V83, pS39