Enantioselective construction of quaternary carbon centers by catalytic [2+2+2] cycloaddition of 1,6-enynes and alkynes

被引：62

作者：

Shibata, T ^{[1
]}

Arai, Y ^{[1
]}

Tahara, Y ^{[1
]}

机构：

[1] Waseda Univ, Sch Sci & Engn, Dept Chem, Tokyo 1698555, Japan

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 22期

关键词：

D O I：

10.1021/ol051876j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The enantioselective [2 + 2 + 2] cycloaddition of 1,6-enynes and alkynes using chiral rhodium catalysts gave cycloadducts containing quaternary carbon stereocenters. Both symmetrical and unsymmetrical alkynes and acetylene could be used as coupling partners, and the corresponding bicyclic cyclohexa-1,3-dienes were obtained in good to excellent ee.

引用

页码：4955 / 4957

页数：3

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