A Pericyte Origin of Spinal Cord Scar Tissue

被引：665

作者：

Goritz, Christian ^{[1
]}

Dias, David O. ^{[1
]}

Tomilin, Nikolay ^{[2
]}

Barbacid, Mariano ^{[3
]}

Shupliakov, Oleg ^{[2
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Karolinska Inst, Dept Neurosci, SE-17177 Stockholm, Sweden

[3] Ctr Nacl Invest Oncol, Mol Oncol Programme, Madrid 28029, Spain

来源：

SCIENCE | 2011年 / 333卷 / 6039期

基金：

欧洲研究理事会; 瑞典研究理事会;

关键词：

BLOOD-BRAIN-BARRIER; COLLAGEN-PRODUCING CELLS; GLIAL SCAR; FIBROSIS; REGENERATION; FIBROBLASTS; MIGRATION; INJURY; REPAIR; MICE;

D O I：

10.1126/science.1203165

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There is limited regeneration of lost tissue after central nervous system injury, and the lesion is sealed with a scar. The role of the scar, which often is referred to as the glial scar because of its abundance of astrocytes, is complex and has been discussed for more than a century. Here we show that a specific pericyte subtype gives rise to scar-forming stromal cells, which outnumber astrocytes, in the injured spinal cord. Blocking the generation of progeny by this pericyte subtype results in failure to seal the injured tissue. The formation of connective tissue is common to many injuries and pathologies, and here we demonstrate a cellular origin of fibrosis.

引用

页码：238 / 242

页数：5

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