Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

被引：531

作者：

Barnabe-Heider, Fanie ^{[1
]}

Goritz, Christian ^{[1
]}

Sabelstrom, Hanna ^{[1
]}

Takebayashi, Hirohide ^{[2
]}

Pfrieger, Frank W. ^{[3
]}

Meletis, Konstantinos ^{[1
]}

Frisen, Jonas ^{[1
]}

机构：

[1] Karolinska Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden

[2] Kumamoto Univ, Grad Sch Med Sci, Dept Morphol Neural Sci, Kumamoto 8608556, Japan

[3] Univ Strasbourg, Inst Cellular & Integrat Neurosci INCI, CNRS, UPR 3212, F-67084 Strasbourg, France

来源：

CELL STEM CELL | 2010年 / 7卷 / 04期

基金：

加拿大健康研究院; 瑞典研究理事会;

关键词：

GRAY-MATTER ASTROCYTES; NEURAL STEM-CELL; REACTIVE ASTROCYTES; PROGENITOR CELLS; EPENDYMAL CELLS; GAP-JUNCTIONS; SCAR TISSUE; BETA-CELLS; BRAIN; OLIGODENDROCYTES;

D O I：

10.1016/j.stem.2010.07.014

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Several distinct cell types in the adult central nervous system have been suggested to act as stem or progenitor cells generating new cells under physiological or pathological conditions. We have assessed the origin of new cells in the adult mouse spinal cord by genetic fate mapping. Oligodendrocyte progenitors self-renew, give rise to new mature oligodendrocytes, and constitute the dominating proliferating cell population in the intact adult spinal cord. In contrast, astrocytes and ependymal cells, which are restricted to limited self-duplication in the intact spinal cord, generate the largest number of cells after spinal cord injury. Only ependymal cells generate progeny of multiple fates, and neural stem cell activity in the intact and injured adult spinal cord is confined to this cell population. We provide an integrated view of how several distinct cell types contribute in complementary ways to cell maintenance and the reaction to injury.

引用

页码：470 / 482

页数：13

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