Oxazoline-Based Antimicrobial Oligomers: Synthesis by CROP Using Supercritical CO2

被引：32

作者：

Correia, Vanessa G. ^{[1
,2
]}

Bonifacio, Vasco D. B. ^{[1
]}

Raje, Vivek P. ^{[1
]}

Casimiro, Teresa ^{[1
]}

Moutinho, Guilhermina ^{[3
]}

da Silva, Claudia Lobato ^{[4
]}

Pinho, Mariana G. ^{[2
]}

Aguiar-Ricardo, Ana ^{[1
]}

机构：

[1] Univ Nova Lisboa, REQUIMTE, Fac Ciencias & Tecnol, Dept Quim, P-2829516 Caparica, Portugal

[2] Inst Tecnol Quim & Biol, Bacterial Cell Biol Lab, P-2780157 Oeiras, Portugal

[3] Inst Super Ciencias Saude Egas Moniz Quinta Granj, CPB, P-2829516 Caparica, Portugal

[4] Inst Super Tecn, Ctr Biol & Chem Engn, IBB, P-1049001 Lisbon, Portugal

来源：

MACROMOLECULAR BIOSCIENCE | 2011年 / 11卷 / 08期

关键词：

antimicrobial activity; biocompatibility; oligo(2-oxazoline)s; supercritical carbon dioxide; water-soluble polymers; RING-OPENING POLYMERIZATION; POLY(2-OXAZOLINE)S; PEPTIDES; DEFENSE; CHEMISTRY; POLYMERS;

D O I：

10.1002/mabi.201100126

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A method using supercritical CO2 to obtain biocompatible 2-oxazoline-based oligomers quaternized with different amines is described. The synthesized oligo(2-oxazoline)s display partial carbamic-acid insertion at one end. The syntheses of quaternary oligo(2-bisoxazoline)s and linear oligoethylenimine hydrochlorides are reported. Oligo(2-methyl-2-oxazoline) and oligo(2-bisoxazoline) quaternized with N,N-dimethyldodecylamine are the most efficient biocidal agents showing fast killing rates against Staphylococcus aureus and Escherichia coli. Linear oligoethylenimine hydrochloride shows the lowest MIC values but higher killing times against both bacteria. Based on the antimicrobial activity studies, a cooperative action of carbamic acid with the ammonium end group is proposed.

引用

页码：1128 / 1137

页数：10

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