Orthogonal base pairs continue to evolve

被引：8

作者：

Bergstrom, DE ^{[1
]}

机构：

[1] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47907 USA

来源：

CHEMISTRY & BIOLOGY | 2004年 / 11卷 / 01期

关键词：

D O I：

10.1016/j.chembiol.2004.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in the design and construction of unusual analogs of the natural nucleic acid bases have reached a milestone with the report (in this issue of Chemistry & Biology [1]) of a new orthogonal base pair that allows site-specific introduction of a photo-crosslinkable modified base into an RNA molecule by T7 RNA polymerase-mediated transcription of DNA containing the base-pairing partner.

引用

页码：18 / 20

页数：3

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