Long noncoding RNA-mediated anti-apoptotic activity in murine erythroid terminal differentiation

被引：206

作者：

Hu, Wenqian ^{[1
]}

Yuan, Bingbing ^{[1
]}

Flygare, Johan ^{[1
]}

Lodish, Harvey F. ^{[1
,2
,3
]}

机构：

[1] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[2] MIT, Dept Biol, Cambridge, MA 02142 USA

[3] MIT, Dept Bioengn, Cambridge, MA 02142 USA

来源：

GENES & DEVELOPMENT | 2011年 / 25卷 / 24期

关键词：

long noncoding RNA; erythroid terminal differentiation; apoptosis; EVOLUTION; GENOME; CELL;

D O I：

10.1101/gad.178780.111

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Long noncoding RNAs (lncRNAs) are differentially expressed under both normal and pathological conditions, implying that they may play important biological functions. Here we examined the expression of lncRNAs during erythropoiesis and identified an erythroid-specific lncRNA with anti-apoptotic activity. Inhibition of this lncRNA blocks erythroid differentiation and promotes apoptosis. Conversely, ectopic expression of this lncRNA can inhibit apoptosis in mouse erythroid cells. This lncRNA represses expression of Pycard, a proapoptotic gene, explaining in part the inhibition of programmed cell death. These findings reveal a novel layer of regulation of cell differentiation and apoptosis by a lncRNA.

引用

页码：2573 / 2578

页数：6

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