The population biology of the interaction between HIV-1 and HIV-2: Coexistence or competitive exclusion?

被引：27

作者：

Anderson, RM

May, RM

机构：

[1] Ctr. the Epidemiol. of Infect. Dis., Department of Zoology, University of Oxford, Oxford

[2] Ctr. the Epidemiol. of Infect. Dis., Department of Zoology, University of Oxford, Oxford OX1 3PS, South Parks Road

来源：

AIDS | 1996年 / 10卷 / 14期

基金：

英国惠康基金;

关键词：

HIV-1; HIV-2; evolution of virulence; cross-immunity; coexistence; population dynamics;

D O I：

10.1097/00002030-199612000-00011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: The emergence and rapid world-wide spread of HIV provides an unusual opportunity for the study of the evolution and maintenance of virulence in a major human pathogen. Objective: To analyse the available biological and epidemiological data on the pathogenicity, transmissibility and antigenic similarity of HIV-1 and HIV-2, and use simple mathematical models of competition between the two viral types within a defined host community. Results and conclusions: Analysis revealed a positive association between pathogenicity and reproductive success. A mathematical model of the concomitant transmission of the two viruses suggests that HIV-1 will competitively displace HIV-2 in the longer term in areas where both viruses are being transmitted within the same sexually active population.

引用

页码：1663 / 1673

页数：11

共 65 条

[1]

ANDERSON R M, 1986, IMA Journal of Mathematics Applied in Medicine and Biology, V3, P229

[2]

ANDERSON R M, 1991

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