Role of the soluble pattern recognition receptor PTX3 in vascular biology

被引:155
作者
Presta, Marco
Camozzi, Maura
Salvatori, Giovanni
Rusnati, Marco
机构
[1] Univ Brescia, Unit Gen Pathol & Immunol, Dept Biomed Sci & Biotechnol, I-25123 Brescia, Italy
[2] Sigma Tau Res Dept, Rome, Italy
关键词
angiogenesis; atherosclerosis; bacteria; complement; cytokines; extracellular matrix; FGF; pentraxin; restenosis; vasculitis;
D O I
10.1111/j.1582-4934.2007.00061.x
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Pentraxins act as soluble pattern recognition receptors with a wide range of functions in various pathophysiological conditions. The long-pentraxin PTX3 shares the C-terminal pentraxin-domain with short-pentraxins C-reactive protein and serum amyloid P component and possesses an unique N-terminal domain. These structural features suggest that PTX3 may have both overlapping and distinct biological/ligand recognition properties when compared to short-pentraxins. PTX3 serves as a mechanism of amplification of inflammation and innate immunity. Indeed, vessel wall elements produce high amounts of PTX3 during inflammation and the levels of circulating PTX3 increase in several pathological conditions affecting the cardiovascular system. PTX3 exists as a free or extracellular matrix-associated molecule and it binds the complement fraction C1q. PTX3 binds also apoptotic cells and selected pathogens, playing a role in innate immunity processes. In endothelial cells and macrophages, PTX3 upregulates tissue factor expression, suggesting its action as a regulator of endothelium during thrombogenesis and ischaemic vascular disease. Finally, PTX3 binds the angiogenic fibroblast growth factor-2, thus inhibiting its biological activity. Taken together, these properties point to a role for PTX3 during vascular damage, angiogenesis, atherosclerosis, and restenosis.
引用
收藏
页码:723 / 738
页数:16
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