Inhibitory costimulation and anti-tumor immunity

被引：26

作者：

Martin-Orozco, Natalia

Dong, Chen

机构：

[1] Dept Immunol, Houston, TX 77030 USA

[2] Univ Texas, MD Anderson Canc Ctr, Dept Immunol, Houston, TX 77030 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2007年 / 17卷 / 04期

关键词：

costimulation; B7; anti-tumor immunity; tolerance;

D O I：

10.1016/j.semcancer.2007.06.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Costimulation was originally shown to be important in T-cell activation and effector differentiation. Recent characterization of B7/butyrophilin and members of the CD28 superfamily has revealed a large number of negative costimulatory molecules that dampen T-cell activation and regulate immune tolerance. Some of these molecules have been shown to be upregulated in the tumor microenvironment and may serve as potential targets for augmenting anti-tumor immunity. In this article, we summarize recent developments in the field of inhibitory costimulation and discuss the future direction of therapeutic manipulation of inhibitory costimulation in tumor immunotherapy. (c) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：288 / 298

页数：11

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